Kanamycin Sulfate Eye Drops 0.5% 0.4 mL

● Kanamycin is an aminoglycoside antibiotic; it binds to the bacterial 30S ribosomal subunit and inhibits bacterial protein synthesis [1][2] ● Good activity against most Enterobacteriaceae, including Escherichia coli, Klebsiella spp., Proteus spp., Enterobacter spp., Shigella spp., Salmonella spp., Citrobacter spp., Providencia spp. and Yersinia spp.; Haemophilus influenzae, Brucella spp., Neisseria meningitidis and gonococci are mostly susceptible; it is not active against Pseudomonas aeruginosa [1][2] ● Some activity against methicillin-susceptible staphylococci and Mycobacterium tuberculosis; most other Gram-positive bacteria (beta-haemolytic streptococci, Streptococcus pneumoniae, enterococci) and anaerobes are largely resistant; complete cross-resistance exists with streptomycin and neomycin, with partial cross-resistance to other aminoglycosides [1][2] ● A multi-component antibiotic containing kanamycin A, B and C (mainly kanamycin A) [1] ● Clear, colourless to slightly yellow or yellowish-green sterile ophthalmic solution, kanamycin sulfate 0.5% (5 mg/mL), in 0.4 mL single-dose units [1][2][3]

● For topical ocular use only; instil into the conjunctival sac of the affected eye [1][2][3] ● Never inject the product directly into the subconjunctival space or the anterior chamber [1][2] ● Do not allow the bottle tip to touch the eye; keep the container tightly closed after use to avoid contamination [1][2] ● In dacryocystitis associated with blocked nasolacrimal ducts in children, local heat may be applied in addition to the eye drops [1][2] ● Use within 4 weeks of first opening (Chinese registered PI; manufacturer) [1][3]

The schedule below refers to registered kanamycin sulfate eye-drop products of the 0.5% strength; for the single-dose presentation, instil the volume and frequency prescribed in the approved label of the product concerned [1][2].

● Contraindicated in patients with hypersensitivity to kanamycin or to other aminoglycoside antibiotics [1][2] ● Concomitant or sequential topical use with other aminoglycosides may increase ototoxicity, nephrotoxicity and neuromuscular blockade; combined or sequential use with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin) may increase ototoxicity and nephrotoxicity, and topical co-use with cefalotin or cefazolin may increase nephrotoxicity; use caution with other ototoxic or nephrotoxic drugs [1][2] ● Pregnancy and breast-feeding: after instillation the drug is rarely absorbed into the systemic circulation, but the product should not be used in excess in pregnant or lactating women so as to avoid effects on fetal and infant growth and development [1][2] ● Paediatric and geriatric use: no reliable references are available (Chinese registered PI) [1][2] ● Adverse reactions: occasional mild local irritation after instillation; no systemic adverse reactions are expected [1][2] ● Storage: Chinese registered PI — keep sealed in a cool, dark place (protect from light; do not store above 20 °C), shelf life 24 months [1]; manufacturer — store at 15–25 °C, protected from light, keep tightly closed, do not freeze, discard within 4 weeks of first opening [3] For full prescribing information, refer to the approved product label / Summary of Product Characteristics of the product concerned [1][2][3].