Neomycin Sulfate Eye Drops 40000 IU/mL 0.4 mL

● Conjunctivitis, dacryocystitis, keratitis, blepharitis and meibomianitis caused by susceptible organisms, including methicillin-susceptible S. aureus and coagulase-negative staphylococci, H. influenzae, E. coli and Proteus spp. [2] ● Topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria, encompassing conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis [3]

● For topical ocular use only; instil into the conjunctival sac of the affected eye [1][2][3] ● Wash hands before use; do not allow the tip of the container to touch the eye, eyelids, fingers or any surface, and keep the container tightly closed after use [2][3] ● Never inject the product into the eye — do not introduce it directly into the anterior chamber or inject subconjunctivally [2][3] ● Do not share the product with other persons: contaminated ocular products can cause serious eye damage and loss of vision [3]

The schedule below refers to registered neomycin eye-drop products of different strengths; for the single-dose presentation, instil the volume and frequency prescribed in the approved label of the product concerned . Use the lowest effective dose for the shortest possible time appropriate to the infection

● Contraindicated in patients with hypersensitivity to neomycin or to other aminoglycoside antibiotics [2][3] ● Not for injection into the eye: the product must never be introduced directly into the anterior chamber or injected subconjunctivally [2][3] ● Prolonged use may result in overgrowth of non-susceptible organisms, including fungi; bacterial resistance may also develop — if purulent discharge, inflammation or pain becomes aggravated, discontinue and consult a physician [3] ● Topical antibiotics, particularly neomycin, may cause sensitisation — itching, reddening and oedema of the conjunctiva and eyelid, which may manifest simply as failure to heal; discontinue use if such signs are observed [3] ● Allergic cross-reactions may occur which could prevent the future use of kanamycin, paromomycin, streptomycin and possibly gentamicin [3] ● Multi-dose containers can be contaminated by patients (often with concurrent corneal disease or epithelial disruption), which has been associated with bacterial keratitis; discard opened containers as recommended [1][3] ● Pregnancy: use only if clearly needed; breast-feeding: caution should be exercised as excretion in human milk is not known [3] ● Paediatric use: safety and effectiveness not established in the US reference; in children with blocked nasolacrimal ducts, dacryocystitis may be supported by local heat in addition to the eye drops [2][3] ● Adverse reactions: occasional mild local irritation after instillation, with no systemic adverse reactions expected from topical use; rare more serious hypersensitivity reactions (including anaphylaxis) have been reported [2][3] ● Storage: manufacturer — store at 15–25 °C, protected from light, keep tightly closed, do not freeze, discard within 4 weeks of first opening [1]; Chinese PI — protect from light, keep closed, store in a cool place [2]; US reference — store at 15–25 °C, protect from light [3] ● Keep out of the reach of children [3] For full prescribing information, refer to the approved product label / Summary of Product Characteristics of the product concerned [1][2][3][4].