Nitroglycerin 500 mcg per Spray

All nitrates share the same primary pharmacological action: relaxing vascular smooth muscle. Organic nitrates release nitric oxide (NO) in v

Nitroglycerin 500 mcg per Spray product packaging
Syrups

Nitroglycerin 500 mcg per Spray

All nitrates share the same primary pharmacological action: relaxing vascular smooth muscle. Organic nitrates release nitric oxide (NO) in vivo, which activates guanylate cyclase and increases cyclic guanosine monophosphate (cGMP) within smooth muscle cells, thereby relaxing vascular smooth muscle and dilating peripheral arteries and veins — with a more pronounced effect on veins. Venodilation causes blood to pool in the periphery, reducing venous return and lowering left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arterial dilation reduces peripheral vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Coronary dilation increases coronary perfusion. The overall effect is a reduction in myocardial oxygen consumption and an increase in oxygen supply, thereby relieving angina pectoris.

Product NameNitroglycerin 500 mcg per Spray
Dosage FormSyrups
Strength500 mcg per Spray
StandardsBP / ENTERPRISE
Packing1 bottle
DocumentsCOA, COPP, DMF, CTD Dossiers
MOQContact us for MOQ and current stock
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WHO Prescribing Guidance

Indications · Administration · Dosage · Precautions

Reference information summarised from WHO prescribing guidance. Expand each item below — clinical use must always follow the locally approved product insert.

🎯Indications▾
Prevention and treatment of angina pectoris in coronary heart disease.
💧Administration▾
First remove the spray cap, fit the mouthpiece over the actuator, invert the bottle, aim the mouthpiece at the sublingual mucosa, and press the valve — the solution will be sprayed into the mouth as a fine mist.
⚖️Dosage▾
During an acute angina attack, spray 1–2 times onto the oral sublingual mucosa, equivalent to 0.5–1 mg of nitroglycerin.
⚠️Precautions & Warnings▾
(1) Use the minimum effective dose that relieves acute angina; excessive dosage may lead to tolerance. Tablets are for sublingual administration only and must not be swallowed. (2) Small doses may cause severe hypotension, especially in the upright position. The patient should remain in a sitting position when taking sublingual tablets to avoid falls caused by dizziness. (3) Use with caution in patients with hypovolemia or low systolic blood pressure. (4) Hypotension induced by this drug may be accompanied by paradoxical bradycardia and aggravated angina pectoris. (5) May worsen angina caused by hypertrophic obstructive cardiomyopathy. (6) Tolerance to its vascular and anti-anginal effects may develop. (7) Discontinue use if blurred vision or dry mouth occurs. Excessive dosage may cause severe headache.

Reference: WHO Model Formulary / WHO Model List of Essential Medicines. For professional reference only — clinical use must follow the locally approved product insert and national treatment guidelines.

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COA, DMF, dossier and legalization documents for your market registration.

FAQ

Nitroglycerin 500 mcg per Spray — Frequently Asked Questions

Which documents are provided for Nitroglycerin 500 mcg per Spray registration?

Every batch of Nitroglycerin 500 mcg per Spray ships with a Certificate of Analysis (COA). For market registration we provide COPP, DMF and CTD-format dossiers, plus legalisation support where your authority requires it.

What is the MOQ and lead time for Nitroglycerin 500 mcg per Spray?

MOQ and lead time for Nitroglycerin 500 mcg per Spray depend on strength, packaging and destination market. Send us your target market and annual volume — our export team confirms current stock, MOQ and lead time within 24 hours.

Do you support OEM / private label?

Yes. We offer OEM packaging and private-label production for Nitroglycerin 500 mcg per Spray, subject to the regulatory requirements of the destination market.

Which markets have you exported syrups products to?

We have supplied syrups products to 50+ countries across Africa, Southeast Asia, Latin America and the Middle East, with experience in ministry-of-health registration and international tenders.

How is the quality of Nitroglycerin 500 mcg per Spray controlled?

Nitroglycerin 500 mcg per Spray is produced in China-GMP workshops (site re-inspected and passed in 2026), released only after full QC testing against BP / enterprise standards, with retained samples kept for one year beyond the product's expiry date.

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